Epigenetic Reprogramming of the Tumour Microenvironment
Document Type : مقاله پژوهشی
Author
Centre for Molecular Oncology
Abstract
The tumour microenvironment is epigenetically remodelled during progression. We mapped methylation changes in stromal and immune compartments of breast tumours using sorted-population bisulfite sequencing. Cancer-associated fibroblasts acquired a distinct hypomethylated enhancer landscape driving chemokine secretion, while infiltrating T cells showed progressive methylation at effector loci consistent with exhaustion.
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Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 65-77
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