Loss of Tumour Suppressor p53 Drives Genomic Instability
Document Type : مقاله پژوهشی
Author
Institute of Cancer Genomics
Abstract
The tumour suppressor p53 safeguards genome integrity. We modelled p53 loss in organoids and tracked the emergence of structural variation over 40 passages. p53 deficiency produced a rapid accumulation of chromothriptic events concentrated on chromosomes 8 and 17, accompanied by whole-genome doubling in a third of lines. Restoration of p53 function arrested but did not reverse the acquired instability.
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Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 52-64
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