Next-Generation Sequencing of Circulating Tumour DNA for Early Detection
Document Type : مقاله پژوهشی
Author
School of Biological Sciences
Abstract
Circulating tumour DNA enables non-invasive cancer detection. We developed a next-generation sequencing assay targeting methylation and mutation signals simultaneously, validated in a prospective cohort of 1,150 participants. The combined assay achieved 84% sensitivity at 99.4% specificity for stage I-II disease, substantially exceeding mutation-only detection. Tissue-of-origin prediction was correct in 88% of positive cases.
Graphical Abstract
Keywords
Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 39-51
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